Changes of NMDA Receptor Subunit (NR1, NR2B) and Glutamate Transporter (GLT1) mRNA Expression in Huntingtonʼs Disease—An In Situ Hybridization Study
نویسندگان
چکیده
منابع مشابه
بررسی تأثیر محرومیت از بینایی طی دوره بحرانی تکامل مغز بر بیان زیرواحدهای گیرنده NMDA در هیپوکامپ موش صحرایی
Background and purpose: Visual deprivation during critical period of brain development impairs structure and function of NMDA receptors in visual cortex. Parts of visual signals go to the hippocampus through the visual cortex. Therefore, this study aimed at investigating the effects of visual deprivation during critical period of brain development on NMDA receptor subunits expression in rats’ h...
متن کاملEffect of acute exposure to ethanol on distribution of NR1 subunit of NMDA receptor of glutamate in cerebral cortex of chick embryo
Introduction: There is considerable evidence that glutamate-mediated excitatory neurotransmission plays an important role in mediating the behavioral actions of acutely administered ethanol. The aim of the present study was to investigate the effect of acute ethanol exposure on NR1 subunit of NMDA (n-methyl-d-aspartate) receptor distribution in the cerebral cortex of chick embryo on the 10th...
متن کاملAlterations of NMDA receptor subunits NR1, NR2A and NR2B mRNA expression and their relationship to apoptosis following transient forebrain ischemia.
Glutamate excitotoxicity mediated by NMDA receptor activation plays a key role in many aspects of ischemic brain injury, but the expression of NMDA receptor subunits NR1, NR2A and NR2B mRNA and their relationship to apoptosis is still unclear. In this study, we applied in situ hybridization and TUNEL staining to investigate the expression of NMDA receptor subunit mRNA and apoptosis in hippocamp...
متن کاملIncreased Glutamate Receptor and Transporter Expression in the Cerebral Cortex and Striatum of Gcdh-/- Mice: Possible Implications for the Neuropathology of Glutaric Acidemia Type I
We determined mRNA expression of the ionotropic glutamate receptors NMDA (NR1, NR2A and NR2B subunits), AMPA (GluR2 subunit) and kainate (GluR6 subunit), as well as of the glutamate transporters GLAST and GLT1 in cerebral cortex and striatum of wild type (WT) and glutaryl-CoA dehydrogenase deficient (Gchh-/-) mice aged 7, 30 and 60 days. The protein expression levels of some of these membrane p...
متن کاملNR2B subunit of the NMDA glutamate receptor regulates appetite in the parabrachial nucleus.
Diphtheria toxin-mediated, acute ablation of hypothalamic neurons expressing agouti-related protein (AgRP) in adult mice leads to anorexia and starvation within 7 d that is caused by hyperactivity of neurons within the parabrachial nucleus (PBN). Because NMDA glutamate receptors are involved in various synaptic plasticity-based behavioral modifications, we hypothesized that modulation of the NR...
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ژورنال
عنوان ژورنال: Journal of Neuropathology and Experimental Neurology
سال: 1997
ISSN: 0022-3069
DOI: 10.1097/00005072-199704000-00013